Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization
نویسندگان
چکیده
منابع مشابه
Kv1.1 channelopathy abolishes presynaptic spike width modulation by subthreshold somatic depolarization.
Although action potentials propagate along axons in an all-or-none manner, subthreshold membrane potential fluctuations at the soma affect neurotransmitter release from synaptic boutons. An important mechanism underlying analog-digital modulation is depolarization-mediated inactivation of presynaptic Kv1-family potassium channels, leading to action potential broadening and increased calcium inf...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1608763114